Progress in Medicinal Chemistry, Volume 19 (v. 19)

Progress in Medicinal Chemistry, Volume 19 (v. 19)
Author Unknown | 1982-01-15 00:00:00 | Elsevier Science | 354 | Pharmacology
The six reviews in this volume cover once again a most comprehensive range of topics. The anti-malarial activity of the 8-aminoquinolines is examined, with an eye to the development of a single, broad-spectrum drug. Chelation, important in removal of toxic metals from the body, is reviewed for tripositive elements. A new and promising approach to total parenteral nutrition is described. Our indebtedness to the plant origins of many modern drugs is noted in the context of new chemicals. Heterosteroids and receptor-specific opioid peptides constitute two further topics, each case highlighting the wide range of relevant biologically active compounds. Yet another volume challenging the staggering diversity of the field of medicinal chemistry.

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Validation and Qualification in Analytical Laboratories

Validation and Qualification in Analytical Laboratories
Ludwig Huber | 2007-07-23 00:00:00 | Informa Healthcare | 288 | Pharmacology
This Second Edition discusses ways to improve pharmaceutical product quality while achieving compliance with global regulatory standards.  With comprehensive step-by-step instructions, practical recommendations, standard operating procedures (SOPs), checklists, templates, and graphics for easy incorporation in a laboratory. This title serves as a complete source to the subject, and explains how to develop and implement a validation strategy for routine, non-routine, and standard analytical methods, covering the entire equipment, hardware, and software qualification process.  It also provides guidance on qualification of certified standards, in-house reference materials, and people qualification, as well as internal and third party laboratory audits and inspections.

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Nanotherapeutics: Drug Delivery Concepts in Nanoscience

Nanotherapeutics: Drug Delivery Concepts in Nanoscience
Alf Lamprecht | 2008-07-21 00:00:00 | Pan Stanford Publishing | 292 | Pharmacology
An important and exciting aspect in the newly developing field of nanomedicine is the use of nanoparticle drug delivery systems allowing for innovative therapeutic approaches. Due to their small size, these drug delivery systems are promising tools in therapeutic approaches such as selective or targeted drug delivery towards a specific tissue or organ, enhanced drug transport across biological barriers, and intracellular drug delivery.

This timely book provides an overview of possible therapeutic applications. The first part of the book highlights general properties of and phenomena observed with nanoparticles, and the subsequent consequences for applications in drug delivery. The second part focuses on the therapeutic approaches that are possible through the use of nanoparticles, with each chapter discussing a specific disease (e.g. diabetes, cancer, inflammation, etc.) and the relevant therapeutic approaches based on the design of nanoparticulate drug delivery systems. Written in a concise manner, readers will gain an insight into the basics of nanoparticle preparation as well as a more detailed account of what is therapeutically feasible by using nanoparticle approaches.

Contents: General Aspects of Nanotherapeutics: Nanocarriers in Drug Delivery - Design, Manufacture and Physicochemical Properties (C Schmidt & A Lamprecht); Transport Across Biological Barriers (N Nafee et al.); Targeting Approaches (S Cammas-Marion); Disease-Related Approaches by Nanotherapeutics: Nanoscale Cancer Therapeutics (Y Pellequer & A Lamprecht); Nanotherapeutics for Skin Diseases (N Atrux-Tallau et al.); Nanoparticles for Oral Vaccination (J M Irache et al.); Nanoparticles: Therapeutic Approaches for Bacterial Diseases (B Moulari); Nanoparticle Therapy in Parasites Diseases: Possibility and Reality! (M Larabi); Nanocarriers in the Therapy of Inflammatory Disease (A Lamprecht).

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Imidazole and Benzimidazole Synthesis (Best Synthetic Methods)

Imidazole and Benzimidazole Synthesis (Best Synthetic Methods)
M. R. Grimmett | 1997-06-26 00:00:00 | Academic Press | 265 | Pharmacology
Imidazole and Benzimidazole Synthesis is a comprehensive survey of the known methods of syntheses and ring modification. It brings together the multitude of synthesis of the imidazole ring in a systemic way interms of specific bond formation, and recommends the most attractive synthetic approaches. It also collects non-ring-synthetic approaches to classes of compounds such as nitro-, halogeno-, and amino-imidazoles, and covers the synthesis of N-substituted compounds and preparations of specific isomers.

Key Features
* The only book in print dealing specifically with this topic
* Comprehensive survey of the known methods of synthesis and ring modification
* Recommends the most attractive synthetic approaches

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Secrets of Methamphetamine Manufacture: Including Recipes for Mda, Ecstasy, and Other Psychedelic Amphetamines

Secrets of Methamphetamine Manufacture: Including Recipes for Mda, Ecstasy, and Other Psychedelic Amphetamines
Uncle Fester | 1900-01-01 00:00:00 | Loompanics Unlimited | 213 | Pharmacology
For nearly 20 years now I have been training champions, the champions of the field of clandestine chemistry. This book is their training ground.

I cover virtually every possible method of making that "food of the God's" - meth along with how to make it from commonplace materials. I also give coverage of the history of this field, so that newcomers can quickly feel like old pros.

Beyond that, I also supply news inserts with the books so that the latest patents don't leave you in the dust in this rapidly evolving field. This is the place to get up to speed and up to date in this hot area of study.
Reviews
I think the book lacked proper illustrations. In one instance the author refers to a black and white sketch when he says "Making a claisen adapter, as shown in figure 5, is self explanatory". It looks like there is a cork on one end but what material is the rest made of? When working with chemicals, the material your equiptment is made of can be crucial or lifesaving.The author often gets sidetracked with different versions of a recipe. Maybe a different edition would be better?
Reviews
This is a great book that is a little inaccessible to newby chemists, but it's about as simple as the process can be explained. And if you can't understand it you're liable to blow yourself up so I would try something else, theoretically speaking. Since Amazon wont sell this I would direct all interested parties to the Loompanics Unlimited catalog. That's a great catalog in general, and it sells the most updated edition of this book plus others by the author. It also has several other great books. Cheers.
Reviews
while the info is really in this book, it is very hard to read an I feel could be written in more of a layman's term.
Reviews
Finally a resource for the "cooks" out there who know absolutely nothing about what they are doing and end up blowing up their house, or worse yet, their children. "Joe Blow" next door decides he's gonna make some meth and then the cash will roll in, ignoring the fact that the chemicals he's bringing into the neighborhood could very well kill. Maybe, just maybe, this book can cut the casualties of production.
Reviews
This is a wonderful compilation of valuable information by one the great american pioneers of our time! Uncle Fester is the reigning king of the underground enthusiast!

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